Filler Dissolution (Hyaluronidase) Treatment

Filler dissolution (hyaluronidase) is an effective, reliable, and controlled solution for correcting aesthetic and medical complications. The best results are achieved through proper patient selection and experienced physician application.

Procedure Duration :

10 - 20 min

What is Filler Dissolution?

Filler dissolution is a medical procedure that involves the controlled breakdown of hyaluronic acid-based fillers using a special enzyme called hyaluronidase, which helps remove the filler from the body.

This procedure is performed for aesthetic dissatisfaction, asymmetry, excessive filler appearance, or to correct medical complications. Only hyaluronic acid-based fillers can be dissolved; this method is not effective for permanent fillers.

What is Hyaluronidase?

Hyaluronidase is an enzyme that breaks down hyaluronic acid and accelerates its absorption by the body. It has been used safely for many years in medical treatments. In filler dissolution procedures, it is applied in controlled doses.

How is the Treatment Applied?

A detailed patient evaluation is performed.
The type and amount of filler to be dissolved are determined.
If necessary, an allergy test is conducted.
Hyaluronidase is injected into the targeted area.
The procedure typically lasts 10-20 minutes.

In Which Situations is Filler Dissolution Performed?

For Aesthetic Reasons

- Excessive filler appearance (overfilling)
- Unnatural facial expression
- Asymmetry
- Patient dissatisfaction

For Medical Reasons

- Hardness and nodule formation after filler
- Suspected pressure on a blood vessel
- Color change (Tyndall effect – bluish appearance)
- Pain or a feeling of pressure

Those who have had hyaluronic acid fillers but are dissatisfied with the results
Patients who experience complications after filler treatment
Individuals who want to dissolve part or all of their filler.

People with an allergy to hyaluronidase
Pregnant individuals (except in urgent cases)
Individuals who have had permanent fillers (ineffective).

Mild redness
Swelling
Sensitivity

These effects generally subside on their own in a short period.

Edema (swelling)
Asymmetry
Visible filler (Tyndall effect)
Nodule formation

These risks are minimized with proper patient selection and the correct technique.

Cold application and supportive treatments for edema
Filler dissolution with hyaluronidase for asymmetry or excess filler
Medical follow-up if necessary

Yes. In emergency complications such as vascular occlusion (blood vessel blockage), hyaluronidase can be life-saving. Therefore, hyaluronidase should always be available in clinics that perform filler treatments.

The dissolution effect usually starts within hours to days.
In some cases, additional sessions may be needed for complete effect.
The dissolved filler is naturally eliminated by the body.

When performed by an experienced physician, with the correct indications and appropriate dosages, filler dissolution is a safe procedure. It must be performed in a clinic equipped with medical facilities.

Yes. After the necessary waiting period (usually 1–2 weeks), filler can be reapplied in accordance with the facial anatomy. This process should be planned by the physician.