Biostimulant Treatments Skin Rejuvenation and Renewal

Calcium Hydroxylapatite (CaHA) Based Biostimulants

Instead of adding volume to the skin externally, these are injection-based regenerative treatments that stimulate the skin's own production of collagen, elastin, and connective tissue.

Procedure Duration :

20 - 30 min

CaHA-based biostimulants, when injected under the skin, provide immediate structural support while also triggering strong collagen production. CaHA is a biocompatible form of a mineral naturally found in bones and teeth, and it is safely tolerated by the body.

These treatments are ideal for patients seeking more pronounced lifting and firming effects, while also aiming for long-term collagen increase.

How Is the Procedure Done?

Performed under sterile clinical conditions
A local anesthetic cream is applied if necessary
Injections are usually made into the deep dermal or subdermal layers with a cannula
The procedure typically takes 20–30 minutes.

Noticeable tightening and lifting
Increased elasticity
Firming of the face oval
Reduction in fine and moderate-depth wrinkles
Rapid improvement in skin quality
Natural yet strong rejuvenation effect

The results are immediately noticeable and biologically strengthen over time.

Cheeks and mid-face
Jawline
Chin
Temples
Neck
Décolleté
Body areas such as arms and upper knees

👉 Not used on the lips and under-eye area.

Those seeking more pronounced firming and lifting
Patients with moderate sagging
Individuals experiencing a loss of facial contours
Those who want both immediate results and long-term collagen increase
Patients seeking a non-surgical alternative.

Pregnancy and breastfeeding
Active infections or skin conditions
Uncontrolled autoimmune diseases
History of active malignancy (requires medical evaluation)
People with very thin skin and areas requiring superficial treatment.

How Does the Mechanism of Action Work?

After injection, CaHA particles
Create a skeletal-like support under the skin
This results in:
- Mild lifting
- Defined contours
- A more toned appearance
  which are immediately noticeable

Although this effect resembles that of a filler, it does not provide exaggerated volume.

CaHA microspheres activate fibroblasts
Especially Type I collagen production increases significantly
Dermal structure thickens, and skin durability improves

Over time, the carrier gel is absorbed, and the patient’s own collagen replaces it.

The increase in collagen obtained
Lasts for an average of 12–18 months
(This may vary depending on individual factors.)

In most cases, a single session is sufficient
An additional session may be planned if necessary
The effect is noticeable immediately
Maximum biological effect appears within 3–6 months
The duration of results lasts on average 12–18 months.

Mild swelling, redness, and tenderness may occur after application; these effects usually subside within the first 24 hours. During this period, makeup, hot environments, and strenuous exercise should be avoided, and pressure should not be applied to the application area. The early recovery and lifting effect of CaHA is felt quickly; massage is usually not necessary. In the first few weeks, collagen production increases as the gel is absorbed, and the skin gradually gains a firmer, smoother, and more resilient appearance.