Biostimulant Treatments Skin Rejuvenation and Renewal

Polycaprolactone (PCL) Based Biostimulants

These are next-generation injection treatments that, when injected under the skin, both stimulate collagen production and provide controlled structural support.

Procedure Duration :

20 - 30 min

Polycaprolactone (PCL) based biostimulants are injection treatments that, when injected under the skin, stimulate collagen production and provide controlled structural support.
PCL is a biocompatible and biodegradable polymer; it gradually breaks down in the body and is naturally eliminated over time.

These treatments are suitable for patients who wish to see results early and aim for long-lasting, natural rejuvenation.

How Is the Procedure Done?

Performed under sterile clinical conditions
A local anesthetic cream is applied if necessary
Injection is performed with a cannula into the subdermal or deep dermal layer
The procedure typically takes 20–30 minutes.

Skin tightening and firming
Increased elasticity
Reduction in fine and moderate-depth wrinkles
Natural support for facial contours
Significant improvement in skin quality
Both short-term and long-term rejuvenation effects

Results are natural, balanced, and do not alter facial expression.

Overall skin quality improvement on the face
Cheeks and mid-face
Temples
Jawline
Neck
Décolleté
Body areas such as arms and upper knees

👉 Not used on the lips and under-eye area.

Those who want faster results
Individuals with early to moderate sagging
Those needing both firmness and slight support
Patients who don’t want fillers but seek contour support
Individuals aiming for long-term collagen stimulation

Pregnancy and breastfeeding
Active infections or skin conditions
Uncontrolled autoimmune diseases
History of active malignancy (requires medical evaluation)

How Does the Mechanism of Action Work?

After injection, thanks to the microsphere structure of PCL
A slight but controlled support forms under the skin
This effect does not provide sudden volume like fillers; it softly supports the contours

PCL microspheres activate fibroblast cells
Type I collagen synthesis significantly increases
The dermal structure strengthens, and skin thickness and durability improve

Unlike PLLA, PCL induces a sense of clinical improvement at an earlier stage.

Typically, 1–2 sessions are sufficient
Sessions are planned 6–8 weeks apart
The effect begins in the early stages
Maximum results are seen within 4–6 months
The duration of effectiveness lasts for 18–24 months on average.

After PCL-based biostimulant treatments, mild swelling, redness, and tenderness may occur within the first 24 hours; this is normal. During this period, it is advised to avoid makeup, hot showers, saunas, baths, and intense exercise. From the first few days, a feeling of tightening and firming in the skin can be felt, and the risk of firmness or nodules is low. As weeks pass, the sensation of the product fades, and collagen production increases. Within 2–3 months, skin quality significantly improves, and by 4–6 months, the effect reaches its maximum level. The obtained natural and balanced rejuvenation effect typically lasts for 18–24 months.

The increase in collagen lasts on average for 18–24 months (it may vary depending on individual factors).