Biostimulant Treatments Skin Rejuvenation and Renewal

Poly-L-Lactic Acid (PLLA) Based Biostimulants

Poly-L-Lactic Acid (PLLA)-based biostimulants are injection treatments that, when injected under the skin, stimulate the skin's own collagen production in the long term without directly adding volume.

Procedure Duration :

20 - 30 min

Poly-L-Lactic Acid (PLLA) based biostimulants are injection treatments that, when injected under the skin, stimulate the skin’s own collagen production over the long term without providing immediate volume. PLLA is a biocompatible and biodegradable substance that gradually breaks down in the body over time.

These treatments are ideal for patients seeking natural, gradual, and long-lasting rejuvenation.

How Is the Procedure Done?

Performed under sterile clinical conditions
A local anesthetic cream is applied if necessary
Injection is done with a cannula into the subdermal layer
The procedure typically takes 20–30 minutes.

Natural skin tightening and firming
Increased elasticity
Reduction in fine wrinkles
Soft and natural support for facial contours
Significant improvement in skin quality
Long-term rejuvenation

The results are not immediate but increase over time.

For overall skin quality improvement on the face
Cheeks and mid-face
Temples
Jawline support areas
Neck
Décolleté
Body areas such as arms and upper knees

👉 Not used on the lips and under-eye area.

Those seeking natural and gradual rejuvenation
Individuals with early to moderate sagging
Patients who aim for quality and firmness rather than volume
People who are not suitable for fillers but seek collagen stimulation
Those looking for long-lasting effects.

Pregnancy and breastfeeding
Active infections or skin conditions
Uncontrolled autoimmune diseases
History of active malignancy (requires medical evaluation).

How Does the Mechanism of Action Work?

PLLA microparticles activate fibroblast cells
Type I and Type III collagen synthesis increases
Dermal thickness and tissue resilience improve significantly

The main clinical benefit appears during this second phase.

After injection, a slight plumping sensation may occur due to the liquid carrier used
This effect is temporary and does not aim to provide volume

The collagen increase typically lasts 18–24 months.

This duration may vary depending on age, lifestyle, and skin type.

The effects of PLLA are not immediate but appear gradually as collagen is produced. Mild swelling, redness, and tenderness may occur within the first 24 hours; during this time, avoid makeup, hot environments, intense exercise, and pressure on the treated area. Temporary plumping in the first days is normal. Performing regular massages as recommended by the physician (usually following the 5-5-5 rule) helps distribute the product evenly and reduces the risk of nodules. Visible results may not appear in the first weeks; skin tightening begins within 2–3 months due to collagen increase, and natural, long-lasting rejuvenation becomes noticeable within 4–6 months.